1977-1985 B.S. College of Pharmacy, Seoul National University
1985-1987 M.S. Graduate School, Seoul National University
1987-1992 Ph.D. Graduate School, Seoul National University
1992-1994 Post-Doctor, Korea Research Institute of Chemical Technology
1994-1995 Research Associate, Washington State University, USA
1995-present (Assistant, Associate) Professor, College of Pharmacy, Chungbuk National University
2002-2004 Visiting Scholar, Washington State University, USA
2015-2017 Dean, College of Pharmacy, Chungbuk National University
2017-2018 Director, Research Institute for Development of Pharmaceutical Resources, Chungbuk National University
Research Areas
Structures of Bioactive Principles and their Activity Relationships
The Redox Center of a Heat-stable Protein, Rubredoxin
Understanding Cancer
Role of RUNX3 for the ‘R-Point’ in the Cell Cycle
Selected Publications
Yang Bae Kim, Chong-Kook Kim, Il Yeong Park; An Approach to Computer-Aided Drug Design, Pharmacon, 21(1), 20-29 (1991)
X-Z Chi, J-W Lee, Y-S Lee, IY Park, Y Ito and S-C Bae; Runx3 plays a critical role in restriction-point and defense against cellular transformation Oncogene 36, 6884–6894 (2017)
Ryuji Yamazawa, Chimari Jiko, Saehae Choi, Il Yeong Park, Atsushi Nakagawa, Eiki Yamashita, Soo Jae Lee; Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Structure 26(10) 1393-1398 (2018)
Jung-Won Lee, Da-Mi Kim, Ju-Won Jang, Tae-Geun Park, Soo-Hyun Song, You-Soub Lee, Xin-Zi Chi, Il Yeong Park, Jin-Won Hyun, Yoshiaki Ito and Suk-Chul Bae; RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point, Nature Communications 10:1897 (2019)
Soo Jae Lee
043-261-2816
sjlee@chungbuk.ac.kr
Education & Career
2001 Osaka University PhD in Macromolecular Science
1999 Osaka University MS in Macromolecular Science
1989 Seoul National University BS in Pharmacy
1989 – 1996 ChungWae Pharm. Co., Senior Scientist
2002 - 2004 Osaka University, Post-doctoral fellow (Department of Medicine)
2006 - present Chungbuk National University, Professor
(Department of Manufacturing Pharmacy)
2007 - 2009 Chairman, Department of Manufacturing Pharmacy
2017 - 2019 Deputy Dean, College of Pharmacy
Honor and Awards
1996 - 2001 Japanese Government Scholorship(Monbusho Scholarship)
2002 - 2004 JSPS Postdoctoral Fellowship for Foreign Researchers
2004 - 2006 EMBO Fellowship
Research Areas
Our group at Chungbuk National University has been focused on the elucidation of structure-function relationship of protein-protein or protein-RNA complexes, especially nuclear transport related protein complexes including importin- family. A eukaryotic cell is divided into two major compartments, nucleus and cytoplasm by nuclear envelope. Intracellular signals are transmitted via the continuous and bi-directional transport of proteins between the nucleus and the cytoplasm through nuclear pores. To elucidate the molecular basis for such intracellular communication in atomic level, we crystallize and solve the structure of nuclear-transport carrier proteins.
Recently, we expanded our research interests with protein drugs including antibody. Collaboration with Osong KBIO for the X-ray structural analysis of virus antibody-antigen complex are in progress.
Selected Publications
Yamazawa R., Jiko C., Choi S., Park I.Y., Nakagawa A., Yamashita E. a, Lee S.J. a, (2018) Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Structure 2018 Oct 2;26(10):1393-1398 ( a corresponding author)
Song J., Kose S. a, Watanabe A., Son S.Y., Choi S., Hong H., Yamashita E., Park IY., Imamoto N. a, Lee S.J. a (2015) Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):473-83. ( a corresponding author)
Choi S., Yamashita E., Yasuhara N., Song J., Son S.Y., Won Y.H., Hong H.R., Shin Y.S., Sekimoto T., Park I.Y., Yoneda Y. a, Lee S.J. a (2014) Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1050-60. ( a corresponding author)
Wyszynski FJ, Lee SS, Yabe T, Wang H, Gomez-Escribano JP, Bibb MJ, Lee SJ, Davies GJ, Davis BG.(2012) Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nature Chemistry 4, 7, 539-546
Lee S.J a, Jiko C, Yamashita E, Tsukihara T a.(2011) Selective nuclear export mechanism of small RNAs. Curr. Opi. Struct. Biol. 21, 1, 101-108 (a corresponding author)
Okada C*., Yamashita E*., Lee S.J*,a., Shibata S., Katahira J., Nakagawa A., Yoneda Ya., Tsukihara Ta. A high-resolution structure of the pre-microRNA nuclear export machinery Science 27, 326, 1275-1279 ( * equally contributed author, a corresponding author )
Lee S.J., Ogasahara K., Ma J., Nishio K., Ishida M., Yamagata Y., Tsukihara T., Yutani K. (2005) Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon a2b2 Complex Formation : Crystal Structure of the Complex Biochemistry 44, 11417-11427
Lee S.J., Matsuura Y., Liu S.M., Stewart M. (2005) Structural basis for nuclear import complex dissociation by RanGTP. Nature 435, 7042, 693-696.
Tsunehiro M., Takeshi H., Yukiko Y., Lee S.J., Tomoki C., Kazuhiro I, Yoshiki Y., Koichi K., Tomitake T., Keiji T. (2004) Structural basis of sugar-recognizing ubiquitin ligase. Nat. Struc. Mol. Biol., 11, 365-370.
Lee S.J., Sekimoto T., Yamashita E., Nagoshi E., Nakagawa A., Sakai H., Imamoto N., Tsukihara T., Yoneda Y. (2003) The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor. Science. 302, 1571-1575.