• Yong-Moon Lee
  • Ji-Hun Kim
Yong-Moon Lee
043-261-2825
ymleefn@cbnu.ac.kr, ymleefn@hanmail.net

Education:

1982 B.S. Callege of pharmacy, Seoul National University, Korea
1985 M.S. Callege of pharmacy, Seoul National University, Korea
1989 Ph.D. Callege of pharmacy, University of Tokyo, Japan
1994 Guest Researcher Nathional Cancer Institute, NIH, U.S.A

 

Career of international collabortion

1990 Post Doc, Faculties of Pharmaceutical Sciences, University of Tokyo, Japan
1994 Guest Researcher, National Cancer Institute, NIH, U.S.A
1996 Guest Researcher, Department of Biochemistry, College of Pharmacy, Showa University, Tokyo, Japan
1997 Guest Researcher, Budapest Institute of Technology, Budapest, Hungary
1999 Visiting Professor, Kekule Institute, University of Bonn, Germany
2000 Visiting Professor, Department of Biomembrane and Functional Chemistry, Faculties of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
2002 Visiting Professor, Department of Biomembrane and Functional Chemistry, Faculties of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
2004 Research Associate, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA
2007 Guest Researcher, Hungarian Academy of Science, Institute of Enzymology, Budapest, Hungary

 

Research Areas

1) Functional Analysis of Sphingolipid metabolites


2) Regulation and Evaluation of Life-style Disease by S1P

 

Recent Publications

1. Choi S, Kim JA, Kim TH, Li HY, Shin KO, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH. Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via KC a 1.1 upregulation. Aging Cell. 2015 Aug 20. doi: 10.1111/acel.12388. [Epub ahead of print]
2. Shin KO, Kim K, Jeon S, Seo CH, Lee YM, Cho Y. Mass Spectrometric Confirmation of γ-Linolenic Acid Ester-linked Ceramide 1 in the Epidermis of Borage Oil Fed Guinea Pigs. Lipids. 2015 Aug 2. [Epub ahead of print]
3. Jeong SK, Kim YI, Shin KO, Kim BW, Lee SH, Jeon JE, Kim HJ, Lee YM, Mauro TM, Elias PM, Uchida Y, Park K. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Jun 19. pii: S0923-1811(15)30010-4. doi: 10.1016/j.jdermsci.2015.06.007. [Epub ahead of print]
4. ChoHH, Shin KO, Seo CH, Lee SH, Yoo HS, Yoon HR, Kim JW, Lee YM. Quantification of 4-methylimidazole in carbonated beverages by ultra-performance liquid chromatography-tandem mass spectrometry. Arch Pharm Res. 2015 Jul;38(7):1363-8.

 

Contact

1 Chungdae-Ro, Sewon-Ku, Cheonju-City, Chungbuk 28644, Republic of Korea 82-43-261-2825, ymleefn@cbnu.ac.kr

Ji-Hun Kim
043-249-1343
nmrjhkim@chungbuk.ac.kr

Education:

2003 – 2009 : Ph.D. College of pharmacy, Seoul National University
1997 - 2003 : B.S. College of pharmacy, Seoul National University

 

Career

Mar 2017 – Present : Assistant Professor, College of Pharmacy, Chungbuk National University
Mar 2015 – Feb 2017 : Research Professor, Konkuk University Glocal Campus
Jan 2011 – Feb 2015 : Postdoctoral Researcher, Vanderbilt University Medical Center
Mar 2009 – Dec 2010 : Postdoctoral Researcher, College of pharmacy, Seoul National University

 

Research Areas

1. Structural Studies on Membrane proteins

1.1 Caveolin 3

1.2 CD44

2. Engineering of Antibody Drug

3. Structure based Drug Design

 

Selected Publications (2015 - Presnet)


1. DW Sim, Z Lu, HS Won, SN Lee, MD Seo, BJ Lee, JH Kim (2017) Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins, Molecules 22(8) E1347
2. DW Sim*, JW Choi*, JH Kim*, KS Ryu, M Kim, HW Yu, KS Jo, EH Kim, MD Seo, YH Jeon, BJ Lee, YP Kim, HS Won (2017) C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution, FEBS letters 591(7), 1064-1070 (* co-first authors)
3. DW Sim*, JH Kim*, HY Kim*, JH Jang, WC Lee, EH Kim, PJ Park, KH Lee, HS Won (2016) Structural identification of the lipopolysaccharide‐binding capability of a cupin‐family protein from Helicobacter pylori, FEBS letters 590(17), 2997-3004 (* co-first authors)
4. JH Kim, DW Sim, DS Park, TG Jung, SH Lee, TH Oh, JR Ha, SH Seok, MD Seo, HC Kang, YP Kim, HS Won (2016) Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor, Applied Microbiology and Biotechnology 100(24), 10521-10529
5. JH Kim, JP Schlebach, ZL D Peng, KC. Reasoner, CR. Sanders (2016) A pH-mediated topological switch within the N-terminal domain of human Caveolin-3, Biophysical Journal 110(11) 2475-2485
6. JP Schlebach ,PJ Barrett, CA Day, JH Kim, AK Kenworthy , CR Sanders (2016) Topologically diverse human membrane proteins partition to liquid-disordered domains in phase-separated lipid vesicles, Biochemistry 55(7) 985-8
7. DW Sim, YS Lee, MD Seo, HS Won, and JH Kim (2015) A simple guide to the structural study on membrane proteins in detergents using solution NMR, J. Kor. Magn. Reson, 19(3) 137-142
8. KY Lee, JH Kim, YJ Bae, and BJ Lee (2015) pH effect on the structure of reduced NifU–like protein from Helicobacter pylori, J. Kor. Magn. Reson, 19(3) 106-111
9. KY Lee, KY Lee, JH Kim, IG Lee, SH Lee, DW Sim, HS Won, BJ Lee (2015) Structure–based functional identification of Helicobacter pylori HP0268 as a nuclease with both DNA nicking and RNase activities, Nucleic Acids Research 43(10), 5194-207
10. IG Lee, SJ Lee, S Chae, KY Lee, JH Kim, and BJ Lee (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin (TA) system: implications into the design of novel antimicrobial peptides, Nucleic Acids Research 43(15) 7624-37
11. CL Deatherage, Z Lu, JH Kim, and CR Sanders, (2015) Notch transmembrane domain: secondary structure and topology, Biochemistry 54(23) 3565-8