• Myung-Koo Lee
  • Kyung-Eun Lee
Myung-Koo Lee
043-261-2822
myklee@chungbuk.ac.kr

Education & Career

  • 1976 B.S. College of Pharmacy, Chungbuk National University, Korea
  • 1978 M.S. College of Pharmacy, Chungbuk National University, Korea
  • 1988 Ph.D. Faculty of Pharmaceutical Sciences, Kyushu University, Japan
  • 1991-1992 Visiting Scholar, Lab of Molecular Neurobiology, Cornell University Medical Scholl, U.S.A
  • 2001-2018 Director, Research Center for Bioresource and Health, Chungbuk National University, Korea
  • 2002-2004 Dean, College of Pharmacy, Chungbuk National University, Korea
  • 2010-2013 Committee Member, National Science and Technology, Korea
  • 2010-2012 President, The Society of Korean College of Clinical Pharmacy, Korea
  • 1992-present Member, Society for Neuroscience, U.S.A.


International Collaboration

  1. 1995. 12: Univ. of Iowa, USA (Prof. David Min, Clinical Pharmacy Education)
  2. 1997. 7: Univ. of Samford, USA (Prof. Joseph Dean Jr, Clinical Pharmacy Education)
  3. 1999. 1: Kyushu University, Japan (Prof. Yasubumi Sawada, BBB transport)
  4. 2001. 1: Nagasaki University, Japan (Prof. Masaaki Kai, Chemiluminescence and PD animal models)


Research Areas

  1. 1. L-DOPA and Dopamine D1 receptor agonist-induced Neurotoxicity
  2. Anti-neurodegenerative agents including PD
  3. Dopamine biosynthesis and catabolism
    1. 레보도파 및 도파민 효능제의 신경독성 기전
    2. 신경계질환(파킨슨병, 만성스트레스 등) 치료제 개발




Selected Publications

  1. Park HJ, Zhao TT, Park KH, Lee MK. Repeated treatments with the D1 dopamine receptor agonist SKF-38393 modulate cell viability via sustained ERK-Bad-Bax activation in dopaminergic neuronal cells. Beh. Brain Res. 367, 166-175 (2019)
  2. Park HJ, Kang JK, Lee MK. HTHQ ameliorates L-DOPA-induced cytotoxicity in PC12 cells. Molecules 24, 867 (2019)
  3. Davaasambuu U, Park HJ, Park KH, Lee CK, Hwang BY, Lee MK. Ombuoside from Gynostemma pentaphyllum protects PC12 cells from L-DOPA-induced neurotoxicity. Planta Med. 84, 1007-1012 (2018)
  4. Lee OS, Zhang J, Jung SH, Kim HS, Lee MK, Lee HY. High-intensity statin therapy is ‘too much’, thus not indicated for very elderly patients. Pulse 6, 19-31 (2018)
  5. Shin KS, Park HJ, Park KH, Lee KS, Jeong SW, Hwang BY, Lee CK, Lee MK. Effects of gynosaponin TN-2 on L-DOPA-induced cytotoxicity in PC12 cells. NeuroReport, 29, 1-5 (2018)
  6. Zhao TT, Shin KS, Park HJ, Yi BR, Lee KE, Lee MK. Effects of (-)-sesamin on chronic stress-induced anxiety disorders in mice. Neurochem. Res. 42, 1123-1129 (2017)
  7. Zhao TT, kim KS, Shin KS, Park HJ, Kim HJ, Lee KE, Lee MK. Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA. BMC Com. Altern. Med. 17, 449 (2017)
  8. Kim KS, Zhao TT, Shin KS, Park HS, Cho YJ, Lee KE, Kim SH, Lee MK. Gynostemma pentaphyllum ethanol extract protects against memory deficits in an MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA. J. Med. Food 20, 11-18 (2017)
  9. Park HJ, Lee KS, Zhao TT, Lee KE, Lee MK. Effects of asarinin on dopamine biosynthesis and 6-hydroxydopamine-induced cytotoxicity in PC12 cells. Arch. Pharm. Res. 40, 631-639 (2017)
  10. Park HJ, Zhao TT, Lee MK. Animal models of Parkinson's disease and their applications (review). J. Parkinsonism Rest. Legs Syn. 6, 73-82 (2016)


Patents

  1. 아사리닌 또는 (-)-세사민을 함유하는 파킨슨병 예방 또는 치료용 약학조성물 (2015.12 등록).
  2. 덩굴차 추출물을 유효성분으로 함유하는 신경퇴행성 질환의 치료 및 예방용 약학조성물 (2010. 2 등록)
  3. 신경퇴행성 질환의 증상 개선 및 예방을 위한 덩굴차(RCBH) 추출물을 함유하는 건강 기능식품 (2009. 6 등록)
  4. 스트레스 증상의 개선 및 예방을 위한 돌외 추출물 함유 기능성 식품 (2009.6 등록)
Kyung-Eun Lee
043-261-3590
kaylee@chungbuk.ac.kr

Education & Career

  • 1996-2000: BS, College of Pharmacy, Dongduk Womens University
  • 2007-2009: PharmD, College of Pharmacy, Massachusetts College of Pharmacy and Health Science
  • 2011-2013: MS, College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University
  • 2013-2016: PhD, College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University
  • 2001-2004: Quality control pharmacist at Samyang Genex Corp., Korea
  • 2005-2006: Pharmacy intern in Boston Medical Center, USA
  • 2006-2010: Clinical pharmacist in Boston Medical Center, USA
  • 2012: Research pharmacist in Yonsei Severance Cardiovascular Hospital, Korea


Research Areas

  1. Research of gene polymorphism and its clinical implications

     

  2. Pharmacogenetics of warfarin therapy

     

  3. Prospective and retrospective clinical practice studies


Selected Publications

  1. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio. Pharmacogenomics. 2019 May 8
  2. Park JH, Lee KE, Yu YM, Park YH, Choi SA. Incidence and Risk Factors for Venous Thromboembolism After Spine Surgery in Korean Patients. World Neurosurg. 2019 Apr 25
  3. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy. Drug Design, Development and Therapy 2019;13:1717-1727.
  4. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. Cardiovascular Therapeutics 2019;Article ID 1813747
  5. Chung JE, Song GJ, Kim K, Yee J, Kim JH, Lee KE, Gwak HS. Association between anxiety and aggression in adolescents: a cross-sectional study. BMC Pediatrics 2019;19:115
  6. Lee M, Yee J, Kim JY, Kim JY, An SH, Lee KE, Gwak HS. Risk factors for neutropenia and febrile neutropenia following prophylactic pegfilgrastim. Asia Pac J Clin Oncol. 2019 Apr 17.
  7. Kim JH, Yee J, Lee GY, Lee KE, Gwak HS. Comparison of Approval Process for Nonprescription Drugs in Different Countries. Korean J Clin Pharm, 2018;28(4):263-272.
  8. Yi, BR, Kim HJ, Park HS, Cho YJ, Kim JY, Yee J, Chung JE, Kim JH, Lee KE, Gwak HS. Association between MKRN3 and LIN28B polymorphisms and precocious puberty. BMC Genetics 2018;19:47.
  9. Chung JE, Choi SA, Kim KT, Yee J, Kim JH, Seong JW, Seong JM, Kim JY, Lee KE, Gwak HS. Smartphone addiction risk and daytime sleepiness in Korean adolescents. J Paediatr Child Health 2018 Jul;54(7):800-806.
  10. Chung JE, Choi SA, Hwang HS, Park JY, Lee KE, Yee J, Kim YJ, Gwak HS. Association between ß2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor: a prospective observational study. BMC Genetics 2017;18:96.
  11. Baek MY, Hwang HS, Park JY, Chung JE, Lee KE, Lee GY, Seong JW, Yee J, Kim YJ, Gwak HS. Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients. Eur J Clin Pharmacol. 2017 Jul;73(7):837-842.
  12. Lee KE, Chung JE, Cho YJ, Kim HJ, Lee GY, Kim JH, Chang HC, Gwak HS. Influence of NR3C1 and VDR polymorphisms on stable warfarin dose in patients with mechanical cardiac valves. Int J Cardiol. 2017;236:393-397.
  13. An YH, Yu SJ, Kim IS, Kim SH, Moon JM, Kim SH, Choi YH, Choi JS, Im SG, Lee KE, Hwang NS. Hydrogel functionalized Janus membrane for skin regeneration. Adv Healthcare Mater. 2017;6(5):1600795.
  14. BR Lee, KE Lee. Independent Data Monitoring Committees: Review of Current Guidelines. Korean J Clin Pharm, 2016;26(2):181-186.
  15. Lee KE, Kim JH, Chung JE, Lee GY, Cho YJ, Chang BC, Gwak HS Association of inflammatory gene polymorphisms with mechanical heart valve reoperation. Springerplus. 2016;5(1):937.
  16. Park KH, Shin KS, Zhao TT, Park HJ, Lee KE, Lee MK. L-DOPA modulates cell viability through the ERK-c-Jun system in PC12 and dopaminergic neuronal cells. Neuropharmacology. 2016;101:87-97.
  17. Chung JE, Chang BC, Lee KE, Kim JH, Gwak HS. Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves. Eur J Clin Pharmacol 2015;71(10):1229-36.
  18. An SH, Chang BC, Lee KE, Gwak HS. Influence of UDP-Glucuronosyltransferase Polymorphisms on Stable Warfarin Doses in Patients with Mechanical Cardiac Valves. Cardiovasc Ther 2015;33:324-328.
  19. You JB, Choi AY, Baek J, Oh MS, Im SG, Lee KE*, Gwak HS. Application of Monodirectional Janus Patch to Oromucosal Delivery System. Adv. Healthcare Mater. 2015;4:2229-2236.
  20. Kyung Eun Lee PharmD, Byung Chul Chang MD, PhD, Sunny Park, Hye Sun Gwak. Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements. Pharmacogenomics. 2015;16(10):1101-1108.
  21. Moon JY, Lee KE, Chang BC, Jeong E, Jeong H, Gwak HS. Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses. Pharmacogenet Genomics. 2015 Jan 25(1): 38-40.
  22. Park JY, Lee NR, Lee KE, Park S, Kim YJ, Gwak HS. Effects of β2-adrenergic receptor gene polymorphisms on ritodrine therapy in pregnant women with preterm labor: prospective follow-up study. Int J Mol Sci. 2014 Jul 21;15(7):12885-94.
  23. Jeong E, Lee KE, Jeong H, Chang BC, Gwak HS. Impact of GATA4 variants on stable warfarin doses in patients with prosthetic heart valves. Pharmacogenomics J. 2015 Feb;15(1):33-7.
  24. An SH, Lee KE, Chang BC, Gwak HS. Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves. J Clin Pharm Ther. 2014 Jun;39(3):314-8.
  25. Sunny Park, Na Ra Lee, Kyung Eun Lee, Jin Young Park, Young Ju Kim, and Hye Sun Gwak. Effects of single nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor. Drug metab Dispos. 2014 Jan;42(1):40-3.
  26. Kyung Eun Lee, Yun Jung Choi, Byu Ree Oh, In Koo Chun, Hye Sun Gwak, Formulation and in vitro/in vivo evaluation of levodopa transdermal delivery systems. Int J Pharm. 2013; 456: 432-436.
  27. Yoon IK, Choi YJ, Chang BC, Lee KE, Rhie JY, Lee BK, Gwak HS. Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac valves. Arch Pharm Res. 2014 Jun;37(6):752-9.
  28. Lee KE, Hwang SJ, Lee BK, Bae SJ, Gwak HS, Rhie JY. A cross-sectional study of factors related to gastrointestinal drug use in Korean adolescents. Arch Pharm Res. 2013;10:1238-43.
  29. Kim HO, Lee KE, Park HY, Lee NR, Oh BR, Chang BC, Gwak HS. Effects of torsemide on pharmacodynamics and pharmacokinetics of warfarin in humans and rats. J Pharm Pharmacol. 2013; 65(8): 1195-1203.
  30. Kim EJ, Lee KE, Gwak HS. Analysis of Ethnic Differences in Physician’s Desk Reference. Kor J Clin Pharm. 2013; 23(2): 123-128.
  31. Choi AY, Kim CT, Park HY, Kim HO, Lee NR, Lee KE, Gwak HS. Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan. J Agr Food Chem. 2013; 61(9): 2096-2102.
  32. Lee KE, Yoon IK, Lee JK, Chang BC, Gwak HS. Adequate intensity of warfarin therapy for Korean patients with mechanical cardiac valves. J Heart Valve Dis. 2013;22:102-109.
  33. Jung SJ, Lee SS, Lee KE, Lee BK, Gwak HS. Perception and attitude towards antidepressants in Koreans. Kor J Clin Pharm. 2012: 22(1): 65-72.
  34. Lee KE. Milnacipran for treatment of fibromyalgia: A review of clinical trials. Kor J Clin Pharm. 2010; 20(3): 229-234.