Education & Career

• 1996-2000: BS, College of Pharmacy, Dongduk Womens University
• 2007-2009: PharmD, College of Pharmacy, Massachusetts College of Pharmacy and Health Science
• 2011-2013: MS, College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University
• 2013-2016: PhD, College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University
• 2001-2004: Quality control pharmacist at Samyang Genex Corp., Korea
• 2005-2006: Pharmacy intern in Boston Medical Center, USA
• 2006-2010: Clinical pharmacist in Boston Medical Center, USA
• 2012: Research pharmacist in Yonsei Severance Cardiovascular Hospital, Korea

Research Areas

1. Research of gene polymorphism and its clinical implications

    

2. Pharmacogenetics of warfarin therapy

    

3. Prospective and retrospective clinical practice studies

   

Selected Publications

1. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio. Pharmacogenomics. 2019 May 8
2. Park JH, Lee KE, Yu YM, Park YH, Choi SA. Incidence and Risk Factors for Venous Thromboembolism After Spine Surgery in Korean Patients. World Neurosurg. 2019 Apr 25
3. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy. Drug Design, Development and Therapy 2019;13:1717-1727.
4. Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS. Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. Cardiovascular Therapeutics 2019;Article ID 1813747
5. Chung JE, Song GJ, Kim K, Yee J, Kim JH, Lee KE, Gwak HS. Association between anxiety and aggression in adolescents: a cross-sectional study. BMC Pediatrics 2019;19:115
6. Lee M, Yee J, Kim JY, Kim JY, An SH, Lee KE, Gwak HS. Risk factors for neutropenia and febrile neutropenia following prophylactic pegfilgrastim. Asia Pac J Clin Oncol. 2019 Apr 17.
7. Kim JH, Yee J, Lee GY, Lee KE, Gwak HS. Comparison of Approval Process for Nonprescription Drugs in Different Countries. Korean J Clin Pharm, 2018;28(4):263-272.
8. Yi, BR, Kim HJ, Park HS, Cho YJ, Kim JY, Yee J, Chung JE, Kim JH, Lee KE, Gwak HS. Association between MKRN3 and LIN28B polymorphisms and precocious puberty. BMC Genetics 2018;19:47.
9. Chung JE, Choi SA, Kim KT, Yee J, Kim JH, Seong JW, Seong JM, Kim JY, Lee KE, Gwak HS. Smartphone addiction risk and daytime sleepiness in Korean adolescents. J Paediatr Child Health 2018 Jul;54(7):800-806.
10. Chung JE, Choi SA, Hwang HS, Park JY, Lee KE, Yee J, Kim YJ, Gwak HS. Association between ß2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor: a prospective observational study. BMC Genetics 2017;18:96.
11. Baek MY, Hwang HS, Park JY, Chung JE, Lee KE, Lee GY, Seong JW, Yee J, Kim YJ, Gwak HS. Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients. Eur J Clin Pharmacol. 2017 Jul;73(7):837-842.
12. Lee KE, Chung JE, Cho YJ, Kim HJ, Lee GY, Kim JH, Chang HC, Gwak HS. Influence of NR3C1 and VDR polymorphisms on stable warfarin dose in patients with mechanical cardiac valves. Int J Cardiol. 2017;236:393-397.
13. An YH, Yu SJ, Kim IS, Kim SH, Moon JM, Kim SH, Choi YH, Choi JS, Im SG, Lee KE, Hwang NS. Hydrogel functionalized Janus membrane for skin regeneration. Adv Healthcare Mater. 2017;6(5):1600795.
14. BR Lee, KE Lee. Independent Data Monitoring Committees: Review of Current Guidelines. Korean J Clin Pharm, 2016;26(2):181-186.
15. Lee KE, Kim JH, Chung JE, Lee GY, Cho YJ, Chang BC, Gwak HS Association of inflammatory gene polymorphisms with mechanical heart valve reoperation. Springerplus. 2016;5(1):937.
16. Park KH, Shin KS, Zhao TT, Park HJ, Lee KE, Lee MK. L-DOPA modulates cell viability through the ERK-c-Jun system in PC12 and dopaminergic neuronal cells. Neuropharmacology. 2016;101:87-97.
17. Chung JE, Chang BC, Lee KE, Kim JH, Gwak HS. Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves. Eur J Clin Pharmacol 2015;71(10):1229-36.
18. An SH, Chang BC, Lee KE, Gwak HS. Influence of UDP-Glucuronosyltransferase Polymorphisms on Stable Warfarin Doses in Patients with Mechanical Cardiac Valves. Cardiovasc Ther 2015;33:324-328.
19. You JB, Choi AY, Baek J, Oh MS, Im SG, Lee KE*, Gwak HS. Application of Monodirectional Janus Patch to Oromucosal Delivery System. Adv. Healthcare Mater. 2015;4:2229-2236.
20. Kyung Eun Lee PharmD, Byung Chul Chang MD, PhD, Sunny Park, Hye Sun Gwak. Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements. Pharmacogenomics. 2015;16(10):1101-1108.
21. Moon JY, Lee KE, Chang BC, Jeong E, Jeong H, Gwak HS. Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses. Pharmacogenet Genomics. 2015 Jan 25(1): 38-40.
22. Park JY, Lee NR, Lee KE, Park S, Kim YJ, Gwak HS. Effects of β2-adrenergic receptor gene polymorphisms on ritodrine therapy in pregnant women with preterm labor: prospective follow-up study. Int J Mol Sci. 2014 Jul 21;15(7):12885-94.
23. Jeong E, Lee KE, Jeong H, Chang BC, Gwak HS. Impact of GATA4 variants on stable warfarin doses in patients with prosthetic heart valves. Pharmacogenomics J. 2015 Feb;15(1):33-7.
24. An SH, Lee KE, Chang BC, Gwak HS. Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves. J Clin Pharm Ther. 2014 Jun;39(3):314-8.
25. Sunny Park, Na Ra Lee, Kyung Eun Lee, Jin Young Park, Young Ju Kim, and Hye Sun Gwak. Effects of single nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor. Drug metab Dispos. 2014 Jan;42(1):40-3.
26. Kyung Eun Lee, Yun Jung Choi, Byu Ree Oh, In Koo Chun, Hye Sun Gwak, Formulation and in vitro/in vivo evaluation of levodopa transdermal delivery systems. Int J Pharm. 2013; 456: 432-436.
27. Yoon IK, Choi YJ, Chang BC, Lee KE, Rhie JY, Lee BK, Gwak HS. Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac valves. Arch Pharm Res. 2014 Jun;37(6):752-9.
28. Lee KE, Hwang SJ, Lee BK, Bae SJ, Gwak HS, Rhie JY. A cross-sectional study of factors related to gastrointestinal drug use in Korean adolescents. Arch Pharm Res. 2013;10:1238-43.
29. Kim HO, Lee KE, Park HY, Lee NR, Oh BR, Chang BC, Gwak HS. Effects of torsemide on pharmacodynamics and pharmacokinetics of warfarin in humans and rats. J Pharm Pharmacol. 2013; 65(8): 1195-1203.
30. Kim EJ, Lee KE, Gwak HS. Analysis of Ethnic Differences in Physician’s Desk Reference. Kor J Clin Pharm. 2013; 23(2): 123-128.
31. Choi AY, Kim CT, Park HY, Kim HO, Lee NR, Lee KE, Gwak HS. Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan. J Agr Food Chem. 2013; 61(9): 2096-2102.
32. Lee KE, Yoon IK, Lee JK, Chang BC, Gwak HS. Adequate intensity of warfarin therapy for Korean patients with mechanical cardiac valves. J Heart Valve Dis. 2013;22:102-109.
33. Jung SJ, Lee SS, Lee KE, Lee BK, Gwak HS. Perception and attitude towards antidepressants in Koreans. Kor J Clin Pharm. 2012: 22(1): 65-72.
34. Lee KE. Milnacipran for treatment of fibromyalgia: A review of clinical trials. Kor J Clin Pharm. 2010; 20(3): 229-234.

Education & Career

• 1999-2003: BS, College of Pharmacy, Ewha Womans University
• 2011-2014:MS, Graduate School of Clinical Health Sciences, Ewha Womans University
• 2016-2019:Ph. D, College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University
• 2005-2019:Registered Pharmacist, Seoul National University Hospital
• 2019-2020:Postdoctoral Fellow, College of Pharmacy, Ewha Womans University
• 2020-present: Assistant Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. Pharmacovigilance researches in hemato-oncology
   
   
2. Medication use evaluation
   
   
3. Outcomes of Pharmaceutical care service
   
   

Selected Publications

1. Yoo HJ, Han JM, Kim K, Song G, Yee J, Chung JE, Lee JE, Gwak HS. Association between attention deficit hyperactivity disorder and aggression subscales in adolescents. Brain behav. 2021;e02030.
2. Cho YA, Han JM, Kang SY, Kim DC, Youn YJ, Choi KH, Gwak HS. Analysis of risk factors for hepatotoxicity induced by immune checkpoint inhibitors. J Immunother. 2021;44(1):16-21.
3. Yoon HY, Cho YA, Yee J, Gwak HS, Han JM. Clinical and laboratory features of pediatric patients with COVID-19: systematic review and meta-analysis. Korean J Clin Pharm. 2020;30(4):270-278.
4. Yee J, Kim W, Han JM, Yoon HY, Lee N, Lee KE, Gwak HS. Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. Sci Rep. 2020;10(1):18126.
5. Kim W, Han JM, Lee KE. Predictors of mortality in patients with COVID-19: a systematic review and meta-analysis. Korean J Clin Pharm. 2020;30(3):169-176.
6. Yoon HY, Ahn MH, Yee J, Lee N, Han JM, Gwak HS. Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis. Eur J Clin Pharmacol. 2020;76(8):1053-1058.
7. Han JM, Han HW, Yee J, Kim MK, Moon JY, Cho S, Jung D, Cho YS, Seo I, Kim JY, Gwak HS. Factors affecting high-grade hepatotoxicity of tyrosine kinase inhibitors in cancer patients: a multi-center observational study. Eur J Clin Pharmacol. 2020;76(8):1183-1191.
8. Kim K, Yee J, Kim JH, Chung JE, Lee KE, Song G, Han JM, Gwak HS. Health behaviors associated with aggression in Korean adolescents: data from 2 cross-sectional studies. Am J Health Behav. 2020;44(2):271-282.
9. Han JM, Yee J, Chung JE, Lee KE, Park K, Gwak HS. Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects. Mol Genet Genomic Med. 2020;8(5):1201.
10. Yee J, Kim SM, Han JM, Lee N, Yoon HY, Gwak HS. The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis. Sci Rep. 2020;10(1):3658.
11. Han JM, Yee J, Cho YS, Gwak HS. Factors influencing imatinib-induced hepatotoxicity. Cancer Res Treat. 2020;52(1):181-188.
12. Lee N, Park SM, Yee J, Yoon HY, Han JM, Gwak HS. Association between glutathione-S-transferase gene polymorphisms and response to tyrosine kinase inhibitor treatment in patients with chronic myeloid leukemia: a meta-analysis. Target Oncol 2020;15(1):47-54.
13. Moon JY, Lee Y, Han JM, Lee MH, Yee J, Song MK, Kim YJ, Gwak HS. Effects of pharmacist intervention on reducing prescribing errors of investigational drugs in oncology clinical trials. J Oncol Pharm Pract. 2020;26(1):29-35.
14. Han JM, HS Gwak. Reviews on the hepatotoxicity of tyrosine kinase inhibitors. Korean J Clin Pharm. 2019;29(4):223-230.
15. Moon JY, Han JM, Seo I, Gwak HS. Risk factors associated with the incidence and time to onset of lapatinib-induced hepatotoxicity. Breast Cancer Res Treat. 2019;178(1):239-244.
16. Kim MK, Yee J, Cho YS, Jang HW, Han JM, Gwak HS. Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow up study. BMC Cancer. 2018;18(1):988.
17. Jung DS, Han JM, Yee J, Kim JY, Gwak HS. Factors affecting crizotinib-induced hepatotoxicity in non-small cell lung cancer patients. Med Oncol. 2018;35(12);154.
18. Han JM, Ah YM, Suh SY, Jung SH, Hahn HJ, Im SA, Lee JY. Clinical and economic impact of pharmacists' intervention in a large volume chemotherapy preparation unit. Int J Clin Pharm. 2016;38:1124-1132.
19. Bea H, Han J, Lee YH, Kim HS, Lee HS, Lee SH, Heo DS, Lee JY. Polypharmacy in Patients Discharged from Oncology Department. Korean J Clin Pharm. 2013;23(1):42-48.